MK-2048 is primarily used in biomedical research as a potent and selective integrase inhibitor, specifically targeting HIV-1 integrase. It plays a key role in studies related to viral replication mechanisms, particularly in the development of antiretroviral therapies. Due to its high barrier to resistance, MK-2048 is valuable in investigating next-generation HIV treatments that remain effective against drug-resistant strains. It is also employed in pharmacokinetic and preclinical studies to evaluate the efficacy and safety of integrase strand transfer inhibitors (INSTIs). Its long half-life in cellular systems makes it suitable for probing sustained antiviral activity and intracellular drug retention.