Florfenicol is widely used in veterinary medicine as an antibiotic to treat bacterial infections in livestock, poultry, and aquaculture. It is particularly effective against respiratory and systemic infections caused by susceptible organisms, such as Pasteurella, Actinobacillus, and Streptococcus species. In cattle, it is commonly administered to combat bovine respiratory disease (BRD) and foot rot. In swine, it is used to treat swine respiratory disease (SRD) and other bacterial infections. In aquaculture, florfenicol is applied to control diseases like furunculosis in salmon and other bacterial infections in fish. Its broad-spectrum activity and effectiveness against both gram-positive and gram-negative bacteria make it a valuable tool in managing animal health and ensuring food safety. Proper dosage and adherence to withdrawal periods are essential to minimize the risk of antibiotic resistance and ensure compliance with regulatory standards.