Daptomycin is primarily used as an antibiotic to treat serious bacterial infections, particularly those caused by Gram-positive organisms. It is effective against infections like complicated skin and soft tissue infections, bloodstream infections, and endocarditis caused by Staphylococcus aureus, including methicillin-resistant strains (MRSA). Daptomycin works by disrupting the bacterial cell membrane, leading to rapid cell death. It is often reserved for cases where other antibiotics have failed or are unsuitable due to resistance or patient allergies. Its use is typically administered intravenously in hospital settings under close medical supervision to monitor for potential side effects, such as muscle toxicity or kidney issues.