Nadifloxacin is primarily used as a topical antibacterial agent for treating skin infections. It is effective against acne vulgaris, particularly when caused by Propionibacterium acnes, due to its ability to inhibit bacterial DNA gyrase. Additionally, it is applied in the management of secondary bacterial infections in conditions like eczema, dermatitis, and superficial folliculitis. Its broad-spectrum activity against Gram-positive and some Gram-negative bacteria makes it a valuable option for localized skin infections. The formulation is typically available as a cream or lotion, ensuring targeted application with minimal systemic absorption.