Cefamandole sodium is primarily used as an antibiotic in the treatment of various bacterial infections. It is effective against a wide range of Gram-positive and Gram-negative bacteria, making it useful in treating respiratory tract infections, urinary tract infections, skin and soft tissue infections, and bone and joint infections. It is also employed in surgical prophylaxis to prevent infections during and after procedures. Due to its broad-spectrum activity, it is often chosen for infections where the causative organism is not yet identified. It is administered intravenously or intramuscularly, ensuring rapid absorption and distribution in the body. However, its use is typically reserved for cases where other antibiotics may not be effective, considering the potential for resistance and side effects.