Benoxaprofen was developed as a non-steroidal anti-inflammatory drug (NSAID) primarily used for the treatment of rheumatoid arthritis and osteoarthritis. It provided analgesic, anti-inflammatory, and antipyretic effects by inhibiting prostaglandin synthesis through suppression of cyclooxygenase enzymes. The compound demonstrated strong efficacy in reducing joint pain and inflammation, with prolonged duration of action allowing for once-daily dosing. However, its clinical use was discontinued in the early 1980s due to severe hepatotoxicity and phototoxic reactions observed in patients. Despite its withdrawal, benoxaprofen has been used in research settings to study drug-induced liver injury and photosensitivity mechanisms.