3-(1h-1,2,3,4-Tetrazol-5-yl)propan-1-aminehydrochloride
96%
Reagent
Code: #244460
CAS Number
273400-20-7
blur_circular Chemical Specifications
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Molecular Information
Weight
163.61 g/mol
Formula
C₄H₁₀ClN₅
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Registry Numbers
MDL Number
MFCD13186216
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Storage & Handling
Storage
Room temperature
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of antihypertensive drugs like valsartan and related sartan-class medications. The tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the angiotensin II receptor. Its amine functionality allows for easy coupling in multi-step organic syntheses, making it valuable in pharmaceutical development. Also employed in medicinal chemistry for building bioisosteres due to the metabolic stability and polarity of the tetrazole moiety.
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