5-[2-(Trifluoromethoxy)phenyl]-2H-tetrazole
95%
Reagent
Code: #242585
CAS Number
1261268-92-1
blur_circular Chemical Specifications
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Molecular Information
Weight
230.15 g/mol
Formula
C₈H₅F₃N₄O
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Registry Numbers
MDL Number
MFCD18375292
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the preparation of sartan-class antihypertensive drugs such as losartan and valsartan. Its tetrazole ring mimics the carboxylic acid group in biological systems, enhancing binding affinity to the AT1 receptor. It is also employed in medicinal chemistry for developing bioisosteres due to its metabolic stability and improved lipophilicity. Additionally, it finds use in agrochemical research for designing novel active ingredients with enhanced activity and environmental stability.
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