[5-(2-chlorophenyl)-2H-tetrazol-2-yl]acetic acid
97%
science Other reagents with same CAS 5626-38-0
blur_circular Chemical Specifications
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and losartan. Its tetrazole ring mimics the carboxylic acid group in peptides, enhancing binding to the angiotensin II receptor. Commonly employed in pharmaceutical research and development for designing potent and selective blockers of the renin-angiotensin system. Also utilized in medicinal chemistry for constructing bioisosteres to improve metabolic stability and oral bioavailability in drug candidates.
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