5-(Ethylsulfonyl)-1-methyl-1H-tetrazole
98%
Reagent
Code: #184678
CAS Number
1019062-29-3
blur_circular Chemical Specifications
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Molecular Information
Weight
176.2 g/mol
Formula
C₄H₈N₄O₂S
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Storage & Handling
Storage
Room temperature, seal, dry
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as valsartan and irbesartan. Its sulfonyl and tetrazole groups enhance binding affinity to the angiotensin receptor, improving drug efficacy. Also employed in medicinal chemistry for building bioisosteres of carboxylic acids due to the tetrazole ring’s ability to mimic carboxylate functionality while offering better metabolic stability and membrane permeability. Additionally, it finds use in the development of agrochemicals and functional materials where heterocyclic stability and polarity are required.
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