5-[4-(Methylsulfonamido)phenyl]-2H-tetrazole
≥97%
Reagent
Code: #172280
CAS Number
1261268-83-0
blur_circular Chemical Specifications
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Molecular Information
Weight
239.25 g/mol
Formula
C₈H₉N₅O₂S
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Registry Numbers
MDL Number
MFCD18375289
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Storage & Handling
Storage
Room temperature, dry
description Product Description
Used as a key intermediate in the synthesis of angiotensin II receptor antagonists, particularly in the production of sartan-class antihypertensive drugs such as candesartan and valsartan. Its tetrazole ring mimics the carboxylic acid group in angiotensin II, allowing it to effectively bind to the AT1 receptor. This compound contributes to the enhanced bioavailability and receptor affinity of the final drug product. It is also employed in medicinal chemistry research for developing new bioactive molecules due to the tetrazole moiety’s metabolic stability and ability to participate in hydrogen bonding.
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