Indomethacin is widely used as a nonsteroidal anti-inflammatory drug (NSAID) to reduce inflammation, pain, and fever. It is commonly prescribed for conditions such as arthritis, gout, and ankylosing spondylitis to alleviate joint swelling and stiffness. Additionally, it is effective in managing acute pain, including post-surgical discomfort and migraines. In some cases, it is used to treat patent ductus arteriosus in premature infants by promoting the closure of the blood vessel. Its anti-inflammatory properties also make it useful in treating conditions like bursitis and tendonitis. However, it must be used cautiously due to potential side effects on the gastrointestinal and cardiovascular systems.