Amphotericin B is primarily used as an antifungal medication to treat serious fungal infections. It is often administered for systemic infections caused by fungi such as Candida, Aspergillus, and Cryptococcus. It is particularly effective in treating life-threatening conditions like cryptococcal meningitis, invasive candidiasis, and systemic aspergillosis. Due to its broad-spectrum antifungal activity, it is also used in patients with compromised immune systems, such as those undergoing chemotherapy or organ transplants. Additionally, it is employed in cases where other antifungal treatments have failed or are not suitable. The drug is typically given intravenously in hospital settings due to its potent nature and potential side effects. It is also used in liposomal formulations to reduce toxicity while maintaining efficacy.