Triphenylmethanethiol is utilized as a specialty intermediate in organic synthesis, primarily for introducing the tritylthio (TrS-) group as a protecting group for thiols, forming stable thioethers that facilitate selective protection and deprotection in multi-step syntheses. It plays a key role in the development of pharmaceuticals, peptides, nucleosides, and fine chemicals requiring precise control over reactive sulfhydryl functionalities. Additionally, its thiol moiety enables applications as a chain transfer agent in radical reactions and polymerizations. It also serves as a building block for sulfur-containing compounds, including those used in dyes, pigments, and materials science, and can act as a nucleophile to trap carbocations in synthetic methodologies.