Used primarily in organic synthesis as a derivatizing agent for amines and other nucleophiles, enabling the formation of thiourea derivatives which are valuable intermediates in pharmaceutical and agrochemical development. Its electron-withdrawing trifluoromethyl group enhances reactivity and stability of the resulting products, making it useful in the preparation of bioactive compounds and functional materials. Commonly employed in the synthesis of receptor ligands, enzyme inhibitors, anti-cancer agents, and antimicrobials due to the favorable metabolic stability imparted by the trifluoromethyl moiety. Also applied in materials science for constructing conjugated systems and functional polymers with unique electronic properties. Additionally, used as a reagent for labeling proteins or peptides in molecular biology studies, owing to the efficient reactivity of the isothiocyanate group with amine functionalities.