D(-)-Glutamic acid is the D-enantiomer of glutamic acid, a non-proteinogenic amino acid primarily utilized in biochemical research and pharmaceutical synthesis. Unlike its L-isomer, it does not contribute to umami flavor and is not used in food additives like MSG. In research, it is employed to study D-amino acid metabolism, bacterial cell wall structures, and enantioselective processes in biology. In the pharmaceutical sector, it acts as a chiral building block for synthesizing peptides, antibiotics, and drugs targeting neurological conditions, including investigations into its interactions with glutamate receptors and roles in neurotoxicity or neuroprotection. It is also used as an intermediate in organic chemistry for producing enantiomer-specific compounds. Applications in agriculture are limited but include studies on its potential to influence plant growth regulation and stress responses.