Fmoc-Gamma-OH is widely used in peptide synthesis as a protecting group for the gamma-carboxyl group of glutamic acid. Its primary application lies in solid-phase peptide synthesis (SPPS), where it ensures selective deprotection and prevents unwanted side reactions during the assembly of peptide chains. The Fmoc group is easily removed under mild basic conditions, making it ideal for constructing complex peptides with high precision. Additionally, it is employed in the development of peptide-based drugs, biomaterials, and research tools, where controlled and efficient synthesis is crucial. Its stability and compatibility with various coupling reagents further enhance its utility in organic and medicinal chemistry.