S-Adenosyl-L-methionine is widely used in medical and nutritional applications due to its role in methylation, neurotransmitter synthesis, and liver function support. It is commonly used as a dietary supplement for treating depression, where it acts as a methyl donor in the production of neurotransmitters like serotonin and dopamine. It has shown potential in improving mood and reducing symptoms of major depressive disorder, especially in individuals who do not respond well to conventional antidepressants.

It is also used to support liver health, particularly in conditions such as intrahepatic cholestasis, alcoholic liver disease, and drug-induced liver injury. Its ability to enhance glutathione levels helps protect liver cells from oxidative damage.

In osteoarthritis management, S-Adenosyl-L-methionine helps reduce pain and inflammation, with effects comparable to some nonsteroidal anti-inflammatory drugs (NSAIDs), while also supporting cartilage repair.

Additionally, it is being studied for its potential benefits in neurological conditions such as Alzheimer’s disease, Parkinson’s disease, and fibromyalgia, due to its involvement in cellular repair and antioxidant mechanisms.