N-Fmoc-N,O-dimethyl-L-serine
98%
Reagent
Code: #220595
CAS Number
1569103-64-5
blur_circular Chemical Specifications
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Molecular Information
Weight
355.38 g/mol
Formula
C₂₀H₂₁NO₅
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Storage & Handling
Storage
2-8°C
description Product Description
Widely used in solid-phase peptide synthesis, this compound serves as a protected N-methyl amino acid building block, enabling the controlled assembly of complex peptides with N-methylated residues. The Fmoc group provides temporary protection for the N-methylated amine functionality, allowing selective deprotection under mild basic conditions without affecting other sensitive groups. The O-methyl ether protects the serine hydroxyl group, preventing unwanted side reactions during coupling steps. Its stability and compatibility with Fmoc-strategy protocols make it valuable for synthesizing modified peptides, particularly those requiring precise post-translational modifications, N-methylation for enhanced metabolic stability, or peptidomimetic structures. It is commonly employed in the production of pharmaceutical intermediates, bioactive peptides, and research compounds in medicinal chemistry.
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