DBCO-PEG4-amine is widely used in bioconjugation and click chemistry applications due to its unique properties. The DBCO (dibenzocyclooctyne) group enables strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, which are highly efficient and do not require a catalyst. This makes it ideal for labeling biomolecules such as proteins, antibodies, and nucleic acids without disrupting their functionality. The PEG4 spacer provides flexibility and solubility, enhancing the stability and biocompatibility of the conjugated products. It is commonly employed in drug delivery systems, diagnostic assays, and the development of bioconjugate therapeutics. Additionally, its amine group allows for further functionalization, enabling the attachment of various targeting moieties or imaging agents. This versatility makes it a valuable tool in biomedical research and therapeutic development.