Used as a highly effective coupling reagent in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). Its fluorinated benzenesulfonate structure enhances solubility and stability in polar solvents, allowing for efficient activation of carboxylic acids. The compound enables rapid amide bond formation with minimal racemization, making it valuable in the production of complex peptides and proteins. It is also employed in bioconjugation reactions, where selective and clean coupling is required under mild conditions. Due to its chemoselectivity, it is favored in multi-step syntheses of pharmaceuticals and biologically active molecules.