CCT251236 is primarily utilized in the field of cancer research due to its role as a potent and selective inhibitor of WNT signaling. This pathway is often dysregulated in various cancers, making CCT251236 a valuable tool for studying tumor growth and progression. Researchers employ it to investigate the mechanisms of WNT-dependent cancers, such as colorectal and breast cancer, and to explore potential therapeutic strategies. Additionally, it is used in preclinical studies to assess the efficacy of targeting WNT signaling in inhibiting cancer cell proliferation and metastasis. Its application extends to drug discovery, where it serves as a reference compound for developing new WNT pathway inhibitors with improved pharmacological properties.