Used in research to study Wnt signaling pathways, particularly in angiogenesis and eye development. Binds to Wnt ligands and is employed in protein interaction studies, immunoassays, and receptor-ligand binding experiments. The Fc tag enables easy detection and purification, making it valuable in cellular and molecular biology applications. Commonly used in studies related to retinal vascular development and diseases like familial exudative vitreoretinopathy (FEVR).