Used in research to study Wnt signaling pathways, particularly in developmental biology and cancer research. Binds to Wnt ligands and modulates cellular responses, making it valuable for investigating receptor-ligand interactions. Commonly employed in protein-protein interaction assays, ELISA, and surface plasmon resonance (SPR) due to the Fc tag, which also allows easy detection and purification. Supports drug discovery efforts targeting Wnt-related diseases by serving as a soluble receptor decoy in functional studies.