Used as a key reagent in organic synthesis, particularly in the preparation of ketones through the Weinreb–Nahm amide pathway. It reacts with organometallic reagents such as Grignard or organolithium compounds to provide stable intermediates that yield ketones selectively, avoiding over-addition and reducing the formation of by-products. Commonly employed in pharmaceutical synthesis where precise carbonyl construction is required. Its ability to control reactivity makes it valuable in multi-step synthesis of complex molecules, including natural products and active pharmaceutical ingredients.