(E)-Methyl 3-iodoacrylate is widely used in organic synthesis as a versatile building block, particularly in the formation of complex molecules through cross-coupling reactions. It serves as a key intermediate in the preparation of pharmaceuticals, agrochemicals, and fine chemicals. Its iodine moiety makes it highly reactive in palladium-catalyzed reactions, such as the Heck reaction, enabling the creation of carbon-carbon bonds. Additionally, it is employed in the synthesis of acrylate derivatives, which are essential in polymer chemistry for developing materials with specific properties. Its application extends to the production of bioactive compounds and natural product analogs, showcasing its importance in medicinal chemistry and drug discovery.