BM 15766 sulfate is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), primarily utilized in medical research for studying cardiovascular diseases, particularly atherosclerosis and lipid metabolism disorders. It serves as a tool compound to investigate mechanisms of cholesterol esterification in macrophages and foam cell formation, aiding in the evaluation of potential therapeutic agents for hypercholesterolemia and related conditions. Researchers employ it to explore effects on vascular function and lipid accumulation, providing insights into treatments for hypertension, coronary artery disease, and other circulatory disorders. Additionally, it acts as a reference substance in pharmacological studies to compare novel compounds targeting ACAT pathways, advancing drug discovery in cardiovascular health.