(±)-Cromakalim is primarily used as a potassium channel activator, making it valuable in research focused on cardiovascular diseases. It helps in studying vasodilation mechanisms by opening ATP-sensitive potassium channels in smooth muscle cells, leading to relaxation of blood vessels. This property is particularly useful in investigating treatments for hypertension and angina. Additionally, it serves as a tool in pharmacological studies to understand the role of potassium channels in various physiological and pathological processes. Its application extends to experimental models for ischemic heart disease, where it aids in reducing cardiac workload and improving blood flow. Researchers also utilize it to explore its potential protective effects in conditions involving oxidative stress and cellular damage.