BMS-654457 is primarily investigated for its potential therapeutic applications in the field of cardiovascular diseases. It acts as a selective agonist for the apelin receptor, which plays a significant role in regulating blood pressure and cardiovascular function. Research suggests that it may be useful in treating conditions such as heart failure by promoting vasodilation and improving cardiac output. Additionally, its role in modulating fluid homeostasis and vascular tone makes it a candidate for further exploration in managing hypertension and other related disorders. Preclinical studies continue to evaluate its efficacy and safety for potential clinical use.