tert-butyl4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butanoate
97%
Reagent
Code: #244547
CAS Number
2435783-77-8
science Other reagents with same CAS 2435783-77-8
blur_circular Chemical Specifications
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Molecular Information
Weight
473.48 g/mol
Formula
C₂₃H₂₇N₃O₈
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Registry Numbers
MDL Number
MFCD31630743
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Storage & Handling
Storage
Room temperature
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly PROTACs (Proteolysis Targeting Chimeras). It links E3 ligase ligands to target protein binders, enabling selective degradation of disease-related proteins. Its structure supports the formation of bifunctional molecules that recruit cereblon E3 ubiquitin ligase, leading to ubiquitination and subsequent degradation of specific cellular proteins by the proteasome. Commonly applied in the development of anticancer agents and treatments for inflammatory and neurodegenerative diseases.
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