Thalidomide-O-C8-Boc

95%

Reagent Code: #244309
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CAS Number 2225148-52-5

science Other reagents with same CAS 2225148-52-5

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 486.56 g/mol
Formula C₂₆H₃₄N₂O₇
inventory_2 Storage & Handling
Storage -20°C

description Product Description

Used in pharmaceutical research for targeted protein degradation, particularly in the development of PROTACs (proteolysis-targeting chimeras). The compound links thalidomide, which binds to the E3 ubiquitin ligase cereblon, to a functional handle via a Boc-protected alkyl chain. This allows for controlled conjugation to target-binding molecules, enabling selective degradation of disease-related proteins. Commonly applied in oncology and immunology research for designing bifunctional degraders with improved stability and specificity. The Boc group offers protection during synthesis, enabling stepwise assembly of complex degrader molecules.

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Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿52,890.00
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Thalidomide-O-C8-Boc
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Used in pharmaceutical research for targeted protein degradation, particularly in the development of PROTACs (proteolysis-targeting chimeras). The compound links thalidomide, which binds to the E3 ubiquitin ligase cereblon, to a functional handle via a Boc-protected alkyl chain. This allows for controlled conjugation to target-binding molecules, enabling selective degradation of disease-related proteins. Commonly applied in oncology and immunology research for designing bifunctional degraders with improv

Used in pharmaceutical research for targeted protein degradation, particularly in the development of PROTACs (proteolysis-targeting chimeras). The compound links thalidomide, which binds to the E3 ubiquitin ligase cereblon, to a functional handle via a Boc-protected alkyl chain. This allows for controlled conjugation to target-binding molecules, enabling selective degradation of disease-related proteins. Commonly applied in oncology and immunology research for designing bifunctional degraders with improved stability and specificity. The Boc group offers protection during synthesis, enabling stepwise assembly of complex degrader molecules.

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