Thalidomide-O-C8-Boc
95%
science Other reagents with same CAS 2225148-52-5
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description Product Description
Used in pharmaceutical research for targeted protein degradation, particularly in the development of PROTACs (proteolysis-targeting chimeras). The compound links thalidomide, which binds to the E3 ubiquitin ligase cereblon, to a functional handle via a Boc-protected alkyl chain. This allows for controlled conjugation to target-binding molecules, enabling selective degradation of disease-related proteins. Commonly applied in oncology and immunology research for designing bifunctional degraders with improved stability and specificity. The Boc group offers protection during synthesis, enabling stepwise assembly of complex degrader molecules.
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