(1-(Tetrahydro-2H-pyran-2-yl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)boronic acid
98%
Reagent
Code: #243382
CAS Number
1141878-45-6
science Other reagents with same CAS 1141878-45-6
blur_circular Chemical Specifications
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Storage & Handling
Storage
2-8°C, dry
description Product Description
Used as a key intermediate in the synthesis of biologically active compounds, particularly in pharmaceutical research. Its boronic acid functional group enables Suzuki-Miyaura cross-coupling reactions, allowing the formation of carbon-carbon bonds in drug discovery pipelines. Commonly employed in the development of kinase inhibitors and other therapeutic agents where trifluoromethyl and pyrazole motifs enhance metabolic stability and binding affinity. The tetrahydro-2H-pyran-2-yl (THP) protecting group improves solubility and stability during synthesis, and can be easily removed under mild acidic conditions when needed. Valuable in medicinal chemistry for constructing complex molecules with high selectivity and yield.
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