TCS 1105 is primarily used as a selective antagonist for the TRPV1 receptor, which plays a key role in pain sensation and thermoregulation. It is widely applied in research settings to study pain pathways, particularly in models of inflammatory and neuropathic pain. Due to its ability to block capsaicin-induced responses without affecting baseline thermal sensitivity in some studies, it serves as a valuable tool for dissecting the role of TRPV1 in various physiological and pathological conditions. It has also been explored for its potential in developing new analgesic therapies, especially where traditional pain medications have limited efficacy or undesirable side effects. Its application extends to preclinical studies investigating migraine, bladder disorders, and chronic cough, where TRPV1 overactivity is implicated.