2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside, commonly known as phloridzin, is a natural dihydrochalcone glucoside found in apple tree bark and other Rosaceae plants. It serves as a natural sweetening agent due to its intense sweetness (approximately 300-500 times that of sucrose) and low caloric content, making it suitable for sugar substitutes in diabetic and weight-management products. Phloridzin is also studied for its potent antioxidant properties, which help reduce oxidative stress, supporting its use in functional foods, dietary supplements, and cosmetics. In skincare formulations, it inhibits tyrosinase activity to reduce melanin production, fading freckles, age spots, and hyperpigmentation for a brighter complexion. Additionally, its antioxidant effects delay premature aging, prevent wrinkles, and enhance skin resilience against environmental stressors like UV radiation and pollution. Traditionally used in herbal medicine for antidiabetic effects via sodium-glucose cotransporter (SGLT) inhibition, it contributes to the bioactive profile of plant extracts. The glycosidic structure improves water solubility, ideal for beverages, pharmaceuticals, and topical products.