Used in pharmaceutical synthesis as an intermediate for protease inhibitors, particularly in the development of antiviral drugs. Its rigid cyclopropyl-biphenyl structure enhances binding selectivity and metabolic stability. Commonly employed in the preparation of hepatitis C virus (HCV) NS3/4A protease inhibitors due to its ability to mimic peptide motifs while resisting enzymatic degradation. Also utilized in medicinal chemistry for constructing conformationally constrained scaffolds to improve potency and pharmacokinetic properties.