Used in the synthesis of modified oligonucleotides for research applications, particularly in the development of antisense molecules and probes where enhanced stability and specificity are required. Its primary role is to introduce a dimethoxytrityl-protected deoxyuridine residue during solid-phase DNA synthesis. This modification supports efficient coupling and simplifies purification by enabling trityl-on purification strategies. Commonly applied in diagnostic probes, genomics research, and the production of nucleic acid-based therapeutics.