Used topically for the treatment of atopic dermatitis and other inflammatory skin conditions. It works by inhibiting phosphodiesterase 4 (PDE4), which reduces the production of pro-inflammatory mediators in the skin. This helps alleviate symptoms such as redness, swelling, and itching without the side effects commonly associated with corticosteroids. Its non-steroidal nature makes it suitable for long-term management and for use in sensitive populations, including children. Difamilast is formulated as a cream or ointment for localized application, offering targeted relief while minimizing systemic absorption.