2,6-Di-tert-butylpyridinium hexafluorophosphate is the salt form of a sterically hindered, non-nucleophilic pyridine base. The corresponding free base is widely used in organic synthesis for reactions requiring strong basicity without nucleophilic interference, such as the formation of enolates and palladium-catalyzed coupling reactions. The steric bulk of the tert-butyl groups at positions 2 and 6 prevents side reactions, enabling selective deprotonation in complex molecule synthesis. The salt enhances solubility and stability in polar aprotic solvents, making it suitable for electrochemical applications, ion pair stabilization, and as a component in non-nucleophilic electrolyte systems or ionic liquids.