Widely used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions. Its electron-rich phosphine group enhances catalyst stability and activity, making it effective in Suzuki, Heck, and Buchwald–Hartwig aminations. The dimethylamino group can act as a directing group or participate in intramolecular coordination, enabling selective transformations. It is also employed in the development of homogeneous catalysts for C–H activation and asymmetric synthesis. Due to its tunable steric and electronic properties, it supports high turnover numbers and functional group tolerance in complex molecule synthesis, including pharmaceuticals and agrochemicals.