Used in solid-phase oligonucleotide synthesis to introduce a 2′-O-methyl RNA modification with enhanced nuclease resistance and binding affinity. The Dmt (dimethoxytrityl) group enables real-time monitoring of coupling efficiency during synthesis. The phosphoramidite group facilitates covalent linkage to the growing nucleic acid chain. Commonly applied in the production of antisense oligonucleotides, siRNA, and diagnostic probes where improved stability and target specificity are required. The Tac protecting group ensures selective deprotection and minimizes side reactions during synthesis. Ideal for therapeutic and research applications involving RNA interference and gene regulation.