Disperse Blue 359 is primarily used as a dye in the textile industry, especially for dyeing synthetic fibers such as polyester, acetate, and nylon. It provides a bright blue shade with good color fastness to washing and light exposure, making it suitable for high-quality fabrics used in apparel and home textiles. The dye is applied through high-temperature dyeing methods or carrier-based processes, ensuring deep and uniform penetration into the fiber.

It is also employed in the coloring of plastic materials and in some ink formulations where water-insoluble dyes with strong chroma are required. Due to its disperse nature and fine particle size, it remains stable in aqueous dispersion, facilitating even dyeing and reducing batch variation.

Additionally, Disperse Blue 359 finds use in specialty applications such as in the production of security inks and optical sensors, where its distinct absorption and fluorescence properties are utilized. However, care must be taken during handling to avoid inhalation of dust and environmental release, as azo dyes can degrade into potentially harmful aromatic amines under certain conditions.