Used as a silyl protecting group in organic synthesis, particularly for alcohols and phenols. The di-tert-butylmethylsilyl (DTBMS) group offers high stability under a variety of reaction conditions, including basic and mildly acidic environments, making it suitable for multi-step syntheses. It is more sterically hindered and more stable toward hydrolysis than smaller silyl groups like TMS or TBS, allowing selective deprotection in the presence of other silyl-protected functionalities. Commonly employed in the synthesis of complex natural products and pharmaceuticals where robust protection is required.