Widely used as a sulfonylating agent in organic synthesis, particularly in the preparation of sulfonamides and sulfonate esters. Its reactivity makes it valuable for introducing the 2,6-dimethoxybenzenesulfonyl (DMS) group, which acts as a protecting group for amines due to its stability under various reaction conditions. The DMS-protected amines are especially useful in peptide synthesis and other multi-step syntheses where selective deprotection is required. It is also employed in the development of pharmaceuticals and agrochemicals, where controlled functionalization of nitrogen-containing compounds is critical. The compound’s steric and electronic properties enhance selectivity in sulfonylation reactions, improving yield and purity in complex molecule assembly.