c-Fms-IN-1 is primarily utilized in research settings to study and inhibit the activity of the colony-stimulating factor-1 receptor (CSF-1R), also known as c-Fms. This receptor plays a critical role in the regulation and survival of macrophages and monocytes. By targeting CSF-1R, c-Fms-IN-1 helps researchers investigate the role of these immune cells in various diseases, particularly in cancer and inflammatory disorders. In cancer research, it is used to explore the tumor microenvironment, where tumor-associated macrophages (TAMs) often promote tumor growth and metastasis. Inhibiting CSF-1R with c-Fms-IN-1 can reduce TAM activity, potentially slowing tumor progression. Additionally, it is employed in studies related to autoimmune diseases and chronic inflammation, where macrophages contribute to tissue damage. Its application provides valuable insights into the development of therapeutic strategies targeting macrophage-driven pathologies.