(-)-Terreic acid is a fungal metabolite from Aspergillus terreus, known for its biological activities. It exhibits antibiotic properties, particularly against Gram-positive bacteria and fungi, and acts as a kinase inhibitor, targeting enzymes such as protein kinase C (PKC) and tyrosine kinases involved in cellular signaling pathways. These properties make it valuable in research for antimicrobial agents, cancer therapeutics where dysregulated kinase activity is implicated, and as a biochemical probe for enzyme mechanisms and cellular processes. Ongoing studies investigate its therapeutic potential and synthetic analogs for improved efficacy.