Dovitinib (TKI-258, CHIR-258)
≥99%
Reagent
Code: #77589
CAS Number
405169-16-6
blur_circular Chemical Specifications
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Molecular Information
Weight
392.43 g/mol
Formula
C₂₁H₂₁FN₆O
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Registry Numbers
MDL Number
MFCD10565680
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Storage & Handling
Storage
-20°C
description Product Description
Dovitinib is primarily used in the treatment of various cancers due to its ability to inhibit multiple tyrosine kinases, which play a critical role in cancer cell growth and survival. It is particularly studied in renal cell carcinoma (RCC), where it targets pathways like VEGF and FGF, which are often dysregulated in this type of cancer. Additionally, it has shown potential in treating gastrointestinal stromal tumors (GIST) and certain types of breast cancer by blocking signaling pathways that promote tumor progression. Dovitinib is also being explored in combination therapies to enhance its efficacy and overcome resistance to other cancer treatments. Its broad-spectrum kinase inhibition makes it a versatile candidate for targeting multiple oncogenic pathways simultaneously.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | White to beige to yellowish green powder |
| Purity (%) | 99-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
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