TAE-226 is primarily utilized in research settings as a potent and selective inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Its application is significant in studying cancer biology, as it helps in understanding the role of FAK and PYK2 in tumor growth, metastasis, and angiogenesis. Researchers use TAE-226 to explore its potential in disrupting signaling pathways that promote cancer cell survival and invasion. Additionally, it is employed in preclinical studies to evaluate its efficacy as a therapeutic agent in various cancer models, particularly in cases where FAK overexpression is linked to poor prognosis. Beyond oncology, TAE-226 is also used in studies related to cellular adhesion, migration, and wound healing processes.