Capsazepine is primarily used in research to study the role of TRPV1 receptors in various physiological and pathological processes. It acts as a competitive antagonist of capsaicin, blocking the activation of TRPV1 receptors, which are involved in pain sensation and inflammation. This makes it a valuable tool in neuroscience and pharmacology for understanding pain mechanisms and developing potential pain-relief therapies. Additionally, it is used in studies related to thermal regulation, as TRPV1 receptors are sensitive to heat. Capsazepine has also been explored in research on conditions like neuropathic pain, migraine, and inflammatory diseases, helping to elucidate the pathways involved and identify potential therapeutic targets.