HC-067047 is primarily used in research settings to study the role of TRPV4 channels in various physiological and pathological processes. It acts as a selective TRPV4 antagonist, making it valuable in investigating conditions like pain, inflammation, and osmoregulation. In preclinical studies, it has been employed to explore its potential in treating diseases such as osteoarthritis, pulmonary edema, and bladder dysfunction. Researchers also use it to understand the mechanisms of TRPV4 in cellular responses to mechanical stress and osmotic changes. Its application is largely confined to laboratory experiments aimed at developing therapeutic strategies targeting TRPV4-related pathways.