This chemical is widely used as a reagent in organic synthesis, particularly for the introduction of the trifluoromethanesulfonyl (triflyl) group, which is a strong electron-withdrawing group. It is employed in the preparation of trifluoromethanesulfonamides and triflates, which are valuable intermediates in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. The compound is also utilized in peptide chemistry for the protection of amino groups during synthesis. Its ability to enhance the reactivity of certain functional groups makes it a useful tool in the development of complex organic molecules. Additionally, it finds applications in materials science for modifying the properties of polymers and other advanced materials.